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Table 2 Mean baseline spirometry according to bronchodilator responsiveness status.

From: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial

  Criterion A (∆ % Predicted FEV1≥12% and ≥200 mL) Criterion B (∆ % Predicted FEV1≥15%) Criterion C (∆ % Predicted FEV1≥10%)
  Nonresponder (n = 2750) Responder (n = 3033) Nonresponder (n = 1995) Responder (n = 3788) Nonresponder (n = 3553) Responder (n = 2230)
  Tio (n = 1357) Placebo (n = 1393) Tio (n = 1520) Placebo (n = 1513) Tio (n = 995) Placebo (n = 1000) Tio (n = 1882) Placebo (n = 1906) Tio (n = 1769) Placebo (n = 1784) Tio (n = 1108) Placebo (n = 1122)
Prebronchodilator             
   FEV1 (L) 1.09 ± 0.45 1.07 ± 0.43 1.11 ± 0.36 1.11 ± 0.37 1.29 ± 0.44 1.25 ± 0.42 1.00 ± 0.34 1.01 ± 0.36 1.12 ± 0.43 1.10 ± 0.43 1.08 ± 0.35 1.07 ± 0.36
   FEV1 % predicted 40.7 ± 13.4 40.0 ± 13.2 38.5 ± 10.6 38.6 ± 10.5 45.6 ± 12.2 44.8 ± 12.3 36.3 ± 10.6 36.3 ± 10.6 39.9 ± 13.1 39.6 ± 13.0 38.9 ± 10.1 38.8 ± 10.0
   FVC (L) 2.57 ± 0.86 2.54 ± 0.85 2.69 ± 0.76 2.71 ± 0.80 2.84 ± 0.85 2.81 ± 0.84 2.52 ± 0.76 2.53 ± 0.81 2.65 ± 0.83 2.63 ± 0.84 2.59 ± 0.76 2.61 ± 0.81
Postbronchodilator             
   FEV1 (L) 1.19 ± 0.44 1.16 ± 0.43 1.46 ± 0.39 1.46 ± 0.40 1.36 ± 0.47 1.33 ± 0.45 1.31 ± 0.42 1.32 ± 0.44 1.25 ± 0.44 1.23 ± 0.44 1.46 ± 0.40 1.46 ± 0.41
   FEV1 % predicted 44.4 ± 13.3 43.7 ± 13.1 50.8 ± 11.3 50.9 ± 11.1 48.3 ± 13.0 47.5 ± 13.1 47.5 ± 12.6 47.4 ± 12.4 44.6 ± 12.9 44.2 ± 12.9 52.9 ± 10.5 52.6 ± 10.3
   % ∆ FEV1 10.9 ± 10.2 11.1 ± 10.4 34.6 ± 16.0 34.7 ± 15.9 6.14 ± 6.65 6.16 ± 6.82 32.6 ± 15.2 32.4 ± 15.2 13.8 ± 11.2 13.8 ± 11.5 38.7 ± 16.1 38.6 ± 15.7
   FVC (L) 2.81 ± 0.84 2.79 ± 0.85 3.36 ± 0.80 3.38 ± 0.86 3.02 ± 0.87 3.00 ± 0.88 3.14 ± 0.86 3.15 ± 0.91 2.97 ± 0.85 2.95 ± 0.87 3.30 ± 0.85 3.33 ± 0.90
GOLD Stage (%)             
   II 37.4 34.2 55.9 56.9 49.8 46.6 45.7 45.7 37.0 35.8 63.4 62.2
   III 48.0 50.5 41.2 39.7 41.1 43.3 46.1 45.6 50.1 50.2 35.2 36.4
   IV 14.7 15.4 2.8 3.4 9.0 10.1 8.0 8.6 12.9 14.0 1.2 1.3
  1. Tio = tiotropium; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; GOLD = Global Initiative for Chronic Obstructive Lung Disease.
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