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Table 2 Bivariate analysis of respiratory variables for 93 patients with acute lung injury who were ventilated for more than 6 days

From: Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

Variable

 

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Crs (ml/cm H 2 0)

S

27.6 (8.8)

28.1 (12.3)

29.0(11.1)

28.4 (12.0)

28.5 (10.7)

29.1 (10.5)

 

NS

28.1 (13.0)

25.7 (10.3)

26.6 (12.1)

25.5 (9.6)

25.0 (8.9)

23.4 (8.8)

 

p

0.80

0.35

0.35

0.25

0.13

0.01

Pplat (cm H 2 0)

S

26.4 (6.1)

26.5 (7.0)

26.0 (6.7)

25.6 (5.3)

24.9 (5.1)

23.9 (4.7)

 

NS

26.9 (9.0)

28.5 (8.9)

27.6 (8.3)

27.1 (8.2)

26.6 (6.8)

28.4 (7.5)

 

p

0.74

0.24

0.33

0.31

0.20

<0.01

MV (L/min)

S

10.3 (2.8)

9.7 (2.5)

10.2 (2.6)

9.8 (2.8)

9.9 (3.1)

9.5 (2.7)

 

NS

9.7 (3.9)

10.1 (3.9)

11.1 (4.7)

11.8 (5.9)

10.9 (4.3)

10.5 (3.2)

 

p

0.43

0.59

0.21

0.03

0.20

0.10

FiO 2

S

0.7 (0.2)

0.6 (0.2)

0.6 (0.2)

0.6 (0.2)

0.5 (0.1)

0.5 (0.1)

 

NS

0.8 (0.2)

0.6 (0.2)

0.6 (0.2)

0.6 (0.2)

0.6 (0.2)

0.6 (0.2)

 

p

0.11

0.46

0.25

0.22

0.27

0.02

OI (cmH 2 0/mm Hg)

S

10 (5.8)

12.4 (7.9)

11.9 (7.1)

10.8 (7.1)

11.0 (8.6)

9.6 (5.7)

 

NS

13.9 (10.5)

13.3 (9.8)

13.8 (8.6)

14.2 (8.8)

14.0 (9.8)

14.8 (12.7)

 

p

0.02

0.65

0.28

0.06

0.17

0.02

P/F ratio (cm H 2 0)

S

120.2 (58.1)

133.2 (69.7)

141.7 (59.0)

151.0 (331.2)

165.0 (85.1)

170.4 (87.4)

 

NS

106 (60.8)

119.1 (45.1)

135.9 (61.7)

132.9 (61.9)

129.2 (77.3)

138.1 (65.1)

 

p

0.21

0.22

0.69

0.18

0.02

0.03

PEEP (cm H 2 0)

S

7.5 (2.9)

8.9 (3.0)

9.4 (3.0)

9.2 (3.0)

9.0 (3.2)

8.6 (3.2)

 

NS

8.0 (3.2)

9.6 (3.4)

9.3 (3.6)

9.1 (3.6)

9.4 (3.8)

9.9 (3.8)

 

p

0.45

0.30

0.90

0.89

0.65

0.09

Paw (cm H 2 0)

S

14.8 (4.1)

15.7 (4.9)

16.4 (4.0)

15.6 (3.9)

15.3 (4.2)

14.9 (4.3)

 

NS

15.6 (5.9)

16.6 (5.6)

16.7 (5.8)

16.8 (5.9)

16.3 (5.1)

17.1 (5.4)

 

p

0.47

0.41

0.77

0.26

0.32

0.03

pH

S

7.36 (0.1)

7.40 (0.1)

7.39 (0.05)

7.38 (0.06)

7.39 (0.06)

7.40 (0.05)

 

NS

7.32 (0.1)

7.40 (0.1)

7.39 (0.05)

7.36 (0.07)

7.38 (0.07)

7.34 (0.06)

 

p

0.11

0.77

0.87

0.05

0.32

<0.01

Base Deficit

S

-2.9 (6.0)

-2.2 (5.1)

-1.0 (4.9)

-0.3 (4.2)

0.6 (4.6)

1.6 (4.6)

 

NS

-3.6 (6.4)

-2.3 (4.2)

-1.5 (4.0)

-2.6 (5.1)

-1.6 (5.0)

-1.5 (5.7)

 

p

0.63

0.90

0.58

0.03

0.06

0.01

Vt (ml/kg)

S

7.8 (1.7)

6.6 (1.8)

6.4 (1.4)

6.3 (1.5)

6.2 (1.4)

6.2 (1.3)

 

NS

6.7 (2.1)

6.4 (1.8)

6.5 (1.8)

6.6 (2.5)

6.0 (1.8)

6.0 (1.4)

 

p

0.02

0.65

0.67

0.42

0.51

0.44

  1. Definitions of abbreviations: BD, Base deficit; Crs, respiratory system compliance; FiO2, inspired oxygen fraction; MV, minute ventilation; OI, oxygenation index; PaO2, arterial oxygen partial pressure; PaO2/FiO2, ratio of arterial oxygen partial pressure-to-inspired oxygen fraction; PEEP, positive end-expiratory pressure; mean Paw, Mean airway pressure; Pplat, end-inspiratory plateau pressure; VT, Tidal Volume; S, survivors; NS, nonsurvivors. Data presented as mean (standard deviation).
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Respiratory Research

ISSN: 1465-993X

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