Figure 5
Contribution of Cx 37, 40 and 43 in the contractile response to ET-1. Concentration-response curves to ET-1 were performed in the absence (control, squares) or in the presence of connexin-mimetic peptides targeted against Cx 37 and 43 (37-43Gap27, circles) and 40 (40Gap27, triangles). Each set of experiments was performed on intrapulmonary arteries from normoxic (normoxia, panel A, black symbols, n = 10 - 26), chronic hypoxic (chronic hypoxia, panel B, white symbols, n = 8 - 17) and monocrotaline-injected rats (monocrotaline, panel C, grey symbols, n = 8 - 20). Data are means ± SEM and are expressed as a percentage of the high potassium solution (80 mM)-induced response.