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Figure 2 | Respiratory Research

Figure 2

From: Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma

Figure 2

Effect of albuterol on respiratory mechanics in mice sensitized and challenged with OVA. Balb/C mice were anesthetized and connected to a flexiVent and then received inhalation challenges of aerosolized OVA. The OVA inhalation was repeated 4 times and the respiratory impedance was measured after each challenge as indicated by arrows and numbers on the X-axis as follows: Following OVA inhalation at indicator 1, 2, 3 and 4 respiratory mechanics was measured every 10 seconds for 1 minute; following OVA inhalation at indicator 5 mechanics was measured once every minute for 20 minutes. Parameters from fitting the constant phase model to input impedance data are shown. R n is Newtonian resistance of the conducting airways; H is lung elastance and G is tissue resistance. Animals were treated with (RS)-, (R)- or (S)- albuterol (n = 14, 13 and 15) twice daily for seven days with the last administration 18 hours before experiment. PBS (n = 9) was used as vehicle control. Both H and G were significantly elevated by (RS)-, (R)- and (S)- albuterol compared with control PBS over the 30 - 60 minutes interval (*** p < 0.001). Changes in R n were not statistically significant (p > 0.05).

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Respiratory Research

ISSN: 1465-993X

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