Figure 1

BAL (bronchoalveolar lavage) fluid cell counts, airway hyperreactivity and the mRNA expression of cytokines in ovalbumin (OVA)-challenged wildtype Balb/c mice compared to PBS-challenged controls. A. Absolute number of eosinophils, lymphocytes, macrophages and neutrophils in BAL fluid. B. Bronchial hyperreactivity expressed as enhanced-pause values (Penh) for each concentration of methacholine. C. Relative mRNA expression of pro-inflammatory cytokines TNF-α, Th2 cytokine IL-4 and Th1 cytokine IFN-γ compared to controls. RU = relative expression unit. Results are expressed as mean ± SEM. * p < 0.05, **p < 0.01, ***p < 0.001. n = 8 mice/group.