Figure 2

Outcomes versus ΔFEV ₁ : curves fitted from model-based analysis. SGRQ and TDI data is for Week 24/26. Exacerbations are reported counts normalised to 1 year. Rescue medication use is reported numbers of puffs normalised to 1 day. For plotting predicted curves, 'moderate' refers to baseline FEV₁ 1.595 l (third quartile of observed values) and GOLD 2 (moderate or less [19]); 'severe' refers to baseline FEV₁ 0.95 l (first quartile of observed values) and GOLD 3 (severe or greater [19]). For TDI, 'moderate' and 'severe' refer to BDI at quartiles 2 and 1, respectively. For ΔSGRQ, 'moderate' and 'severe' refer to baseline SGRQ at quartiles 31.3 and 58.13, respectively; ΔFEV₁, change from baseline in trough forced expiratory volume in 1 second; ΔSGRQ, change from baseline in St George's Respiratory Questionnaire; TDI, Transition Dyspnoea Index; GOLD, Global initiative for chronic Obstructive Lung Disease; BDI, Baseline Dyspnoea Index; ICS, inhaled corticosteroid.