Figure 1

The effects of gender on pulmonary vascular remodeling in Mts1+ mice. A: Pulmonary vascular remodeling is increased in Mts1+ female mice compared to wildtype controls, but not in Mts1+ male mice (n = 4-6). Data are expressed as mean ± SEM and analysed by two-way analysis of variance followed by Bonferronis post-test. ***P < 0.001 cf female wildtype & male Mts1+ mice. B: Representative images (x400 magnification) of resistance pulmonary arteries (stained with Elastica Van Gieson) observed in female wildtype, female Mts1+ mice, male wildtype and male Mts1+ mice. Scale bars represent 50 μm.