Time course of selected lung function parameters during infection. Spirometric curves depicting the time course of Tidal Volume (Total volume inspired and expired in one breath) (A, B), Inspiratory plus Expiratory time (Time required for one breath) (C, D) and Expiratory flow at 50% Expiration (EF50) (E, F) of CftrMHH mice and CftrKO and wild type mice after the intratracheal instillation of P. aeruginosa. There are no marked differences for none of the parameters between CF and wild type mice of either genotype. C57BL6/J mice responded stronger to the bacterial infection than FABP mice as indicated by the larger decrease in lung volume (A). As young mice breathe faster than old mice, the overall time for one breath increases with age (C, D).