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Table 4 The effect of exacerbations on biomarkers.

From: COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

Biomarker Exacerbation within 30 days No or Resolved Exacerbations p-value
  N Median (IQR) N Median (IQR)  
Fibrinogen (mg/dL) 33 534.0 (156.0) 157 464.0 (115.0) < 0.001
Interleukin-6 (pg/mL) 30 2.8 (6.0) 151 0.6 (2.6) < 0.001
Surfactant Protein D (ng/mL) 32 132.7 (135.9) 148 101.0 (70.7) 0.011
C-reactive protein (μg/mL) 33 6.96 (6.52) 153 3.98 (6.76) 0.048
  1. Biomarker results at 3 months for COPD subjects with an exacerbation within 30 days of the study visit and COPD subjects with no exacerbations or resolved exacerbations. Values are expressed as median (IQR), p values are based on log transformed results. The table shows those biomarkers that were significantly different between the two groups. Results for the remaining biomarkers are included additional Table 2.