COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

Respiratory Research

Table 4 The effect of exacerbations on biomarkers.

Biomarker	Exacerbation within 30 days		No or Resolved Exacerbations		p-value
	N	Median (IQR)	N	Median (IQR)
Fibrinogen (mg/dL)	33	534.0 (156.0)	157	464.0 (115.0)	< 0.001
Interleukin-6 (pg/mL)	30	2.8 (6.0)	151	0.6 (2.6)	< 0.001
Surfactant Protein D (ng/mL)	32	132.7 (135.9)	148	101.0 (70.7)	0.011
C-reactive protein (μg/mL)	33	6.96 (6.52)	153	3.98 (6.76)	0.048

Biomarker results at 3 months for COPD subjects with an exacerbation within 30 days of the study visit and COPD subjects with no exacerbations or resolved exacerbations. Values are expressed as median (IQR), p values are based on log transformed results. The table shows those biomarkers that were significantly different between the two groups. Results for the remaining biomarkers are included additional Table 2.

ISSN: 1465-993X