Skip to main content

Table 3 Baseline values for biomarkers in which there was no significant difference between COPD subjects and either smoking or non-smoking controls.

From: COPD association and repeatability of blood biomarkers in the ECLIPSE cohort

  COPD Subjects Smoker Controls   Non-smoker Controls  
Biomarker N Median (IQR) N Median (IQR) COPD Subjects vs Smoker Controls N Median (IQR) COPD Subjects vs Non-smoker Controls
Brain-derived neurotrophic growth factor (pg/mL) 200 36640.0 (17870.0) 37 35140.0 (14420.0) 0.656 37 35620.0 (10060.0) 0.381
CCL4 (pg/mL) 201 109.8 (86.0) 37 117.2 (70.0) 0.846 37 89.6 (86.2) 0.183
CCL23 (pg/mL) 201 501.8 (217.0) 37 443.0 (210.6) 0.483 37 468.0 (200.4) 0.178
CCL24 (pg/mL) 193 93.5 (124.0) 36 74.5 (100.0) 0.294 35 60.0 (61.5) 0.089
CXCL5 (pg/mL) 201 1415.0 (1065.0) 37 1265.0 (500.0) 0.144 37 1425.0 (975.0) 0.817
CXCL7 (pg/mL)* 199 34270367 (21359723) 37 36867340 (17597022) 0.582 36 33070725 (16762456) 0.425
CXCL11 (pg/mL) 200 19.8 (15.4) 36 18.4 (17.3) 0.488 36 16.8 (13.3) 0.249
Interferon-γ (pg/mL) 201 0.4 (0.0) 37 0.4 (0.0) 0.346 35 0.4 (0.0) 0.584
Interleukin-1β (pg/mL) 199 0.2 (0.0) 36 0.2 (0.2) 0.185 37 0.2 (0.0) 0.576
Interleukin-10 (pg/mL) 201 0.4 (0.0) 37 0.4 (0.0) 0.697 37 0.4 (0.0) 0.433
Interleukin-15 (pg/mL) 187 0.8 (0.0) 37 0.8 (0.0) 0.227 36 0.8 (0.0) 0.971
Interleukin-17 (pg/mL) 201 0.8 (0.0) 37 0.8 (0.0) 0.630 37 0.8 (0.0) 0.632
Interleukin-1 receptor antagonist (pg/mL) 193 217.4 (269.9) 36 204.6 (127.6) 0.609 34 139.0 (130.0) 0.056
Leptin (pg/mL)* 199 12857.5 (21025.5) 37 10074.8 (16770.9) 0.622 37 13103.6 (26107.2) 0.058
Tissue inhibitor of metalloproteinase-1 (pg/mL) 201 329500.0 (142100.0) 37 285800.0 (128900.0) 0.215 37 255100.0 (149400.0) 0.302
Transforming Growth Factor-α (pg/mL) 197 3.9 (10.0) 36 3.7 (9.7) 0.674 36 1.2 (5.4) 0.056
Tumor necrosis factor receptor type I (pg/mL) 201 1530.0 (655.0) 37 1525.0 (521.4) 0.999 37 1400.0 (600.0) 0.494
Tumor necrosis factor receptor type II (pg/mL) 196 1065.0 (545.0) 37 920.0 (525.0) 0.454 36 915.0 (537.5) 0.930
Tumor necrosis factor-α (pg/mL) 201 2.4 (0.0) 36 2.4 (0.0) 0.178 37 2.4 (0.0) 0.667
  1. Values expressed as median (IQR), p values based on log transformed results adjusted for age and sex. Biomarkers marked with * were measured at a single timepoint.