Figure 5
AR inhibition by oral administration of fidarestat blocks airway hyper-responsiveness and accumulation of inflammatory cells in BAL of RWE-challenged mice. (A) The changes in PENH were measured by whole-body plethysmography. Mice were placed in a barometric plethysmographic chamber and PENH was determined and plotted against the increasing concentration of methacholine. Each data point represents mean±SD (n = 6). *p < 0.05 and **p <0.01 vs. RWE, (B) Eosinophils in the BAL fluid were determined 72 h after RWE-challenge and presented as bar diagram. The bars represent (mean ± SD) eosinophils per ml BAL fluid (n = 6). *p < 0.05 and **p <0.01 vs. RWE. BL, baseline; RWE, ragweed pollen extract; Fida, fidarestat. PENH, enhanced pause.