Figure 5
From: Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells
Effect of simvastatin on DNA fragmentation and PASMC morphology. (A-B) Pro-apoptotic effect of simvastatin reversed by geranylgeranylpyrophosphate (GGPP, 10 μM) and the pan-caspase inhibitor Z-VAD-fmk (Z-VAD, 10 μM), but not by farnesylpyrophosphate (FPP, 10 μM). (C) PASMCs showed characteristic morphological changes (arrows) following simvastatin-treatment (Sim, 1 μM), which were prevented by co-administration of mevalonate (MVA, 100 μM). Data are mean ± SEM of replicate values (n = 4) and representative of independent experiments with non-IPAH (A) and IPAH cell isolates (B). SF = serum free untreated cells.