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Table 2 Clinical baseline and treatment effects of asthmatics receiving placebo or budesonide

From: Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment

 

Placebo

 

Budesonide

p value

Subjects (male/female)

4 (1/3)

 

3 (0/3)

  

Age (years) §

52 (38-64)

 

65 (62-67)

0.091

Disease duration (years) §

9 (0.5-20)

 

9 (5-17)

0.951

Body Mass Index §

29.4 (21.8-34.7)

 

32.0 (28.9-37.0)

0.578

Documented SPT positivity

3¤

 

2¤¤

  
 

Pre

Post

p value

Pre

Post

p value

Δ p value

FEV 1 (% pred.) #

66 ± 12.52

75 ± 8.67

0.662

88 ± 14.42

101 ± 15.72

0.017

0.838

FVC (% pred.) #

78 ± 13.46

84 ± 8.95

0.738

87 ± 13.78

101 ± 15.01

0.143

0.735

FEV 1 /FVC #

0.71 ± 0.06

0.76 ± 0.07

0.472

0.85 ± 0.09

0.83 ± 0.05

0.676

0.424

PD20 (mg of methacholine) #

0.077 ± 0.06*

0.084 ± 0.06

0.382

0.243 ± 0.14

-†

na

na

F E NO #

53 ± 14.85

40 ± 9.76

0.087

46 ± 5.84

32 ± 9.14

0.092

0.880

  1. The demographics of the asthmatics receiving placebo treatment (n = 4) and budesonide treatment (n = 3) showed no significant differences in age, disease duration or body mass index, as determined by a Student's t-test. The clinical measurements, pre and post treatment, were compared using a paired t-test and showed no changes as a result of placebo treatment. Budesonide treatment resulted in a statistically increased FEV1% predicted. No significant differences were seen for the other variables measured. A p value of < 0.05 was considered statistically significant (shown in bold).
  2. Abbreviations: FEV 1 = forced expiratory volume in 1 sec; FVC = forced vital capacity; PD20 = provocative dose of methacholine producing a 20% decrease in FEV 1 ; F E NO = fractional exhaled nitric oxide; SPT = skin prick test; § = data presented as mean (range); ¤ = 1 patient was SPT negative; ¤¤ = SPT was not performed on 1 patient, but they had no clinical history of allergy; # = data presented as mean ± standard error of the mean; na = not applicable;* = PD20 measurements were only available for three patients; † = PD20 measurement was only available for one patient; Δ = delta change.
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Respiratory Research

ISSN: 1465-993X

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