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Table 2 Clinical baseline and treatment effects of asthmatics receiving placebo or budesonide

From: Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment

  Placebo   Budesonide p value
Subjects (male/female) 4 (1/3)   3 (0/3)   
Age (years) § 52 (38-64)   65 (62-67) 0.091
Disease duration (years) § 9 (0.5-20)   9 (5-17) 0.951
Body Mass Index § 29.4 (21.8-34.7)   32.0 (28.9-37.0) 0.578
Documented SPT positivity 3¤   2¤¤   
  Pre Post p value Pre Post p value Δ p value
FEV 1 (% pred.) # 66 ± 12.52 75 ± 8.67 0.662 88 ± 14.42 101 ± 15.72 0.017 0.838
FVC (% pred.) # 78 ± 13.46 84 ± 8.95 0.738 87 ± 13.78 101 ± 15.01 0.143 0.735
FEV 1 /FVC # 0.71 ± 0.06 0.76 ± 0.07 0.472 0.85 ± 0.09 0.83 ± 0.05 0.676 0.424
PD20 (mg of methacholine) # 0.077 ± 0.06* 0.084 ± 0.06 0.382 0.243 ± 0.14 - na na
F E NO # 53 ± 14.85 40 ± 9.76 0.087 46 ± 5.84 32 ± 9.14 0.092 0.880
  1. The demographics of the asthmatics receiving placebo treatment (n = 4) and budesonide treatment (n = 3) showed no significant differences in age, disease duration or body mass index, as determined by a Student's t-test. The clinical measurements, pre and post treatment, were compared using a paired t-test and showed no changes as a result of placebo treatment. Budesonide treatment resulted in a statistically increased FEV1% predicted. No significant differences were seen for the other variables measured. A p value of < 0.05 was considered statistically significant (shown in bold).
  2. Abbreviations: FEV 1 = forced expiratory volume in 1 sec; FVC = forced vital capacity; PD20 = provocative dose of methacholine producing a 20% decrease in FEV 1 ; F E NO = fractional exhaled nitric oxide; SPT = skin prick test; § = data presented as mean (range); ¤ = 1 patient was SPT negative; ¤¤ = SPT was not performed on 1 patient, but they had no clinical history of allergy; # = data presented as mean ± standard error of the mean; na = not applicable;* = PD20 measurements were only available for three patients; † = PD20 measurement was only available for one patient; Δ = delta change.