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Figure 5 | Respiratory Research

Figure 5

From: Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

Figure 5

Increased pulmonary inflammation is observed at 24 hours after K. pneumoniae infection in SPC-sICAM-1 mice compared to wild-type mice. SPC-sICAM-1 mice and wild-type mice were intranasally inoculated with 250 CFU of K. pneumoniae. After 24 hours, the animals were euthanized, and whole lung lavage was performed. Whole lung lavage was also collected from mice inoculated with PBS, but not exposed to K. pneumoniae, for comparison. Total number of cells was determined by counting with a hemacytometer (A). Representative histologic sections of lungs in wild type (B) and SPC-sICAM-1 mice (C) 24 hours after infection. Data are expressed as mean ± SEM. (n = 6 in all groups; * P < 0.05 compared with wild-type).

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Respiratory Research

ISSN: 1465-993X

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