Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: A randomized controlled trial

Table 2 Changes in Chronic Respiratory Questionnaire

	Change up to 24 months
CRQ total - points
N+R - mean (95% CI)	-3.6 (-10.1 to 2.9)
R - mean (95% CI)	-2.3 (-7.8 to 3.2)
Adjusted difference in change - mean (95% CI)*	-1.3 (-9.7 to 7.4)
CRQ dyspnea - points
N+R - mean (95% CI)	-1.5 (-4.0 to 0.8)
R - mean (95% CI)	0.0 (-2.1 to 2.1)
Adjusted difference in change - mean (95% CI)*	-1.7 (-4.8 to 1.5)
CRQ fatigue - points
N+R - mean (95% CI)	-1.5 (-3.6 to 0.4)
R - mean (95% CI)	-1.5 (-2.9 to 0.2)
Adjusted difference in change - mean (95% CI)*	-0.2 (-2.7 to 2.3)
CRQ emotion - points
N+R - mean (95% CI)	-1.1 (-3.6 to 1.3)
R - mean (95% CI)	-0.4 (-2.5 to 1.7)
Adjusted difference in change - mean (95% CI)*	-0.8 (-4.0 to 2.5)
CRQ mastery
N+R - mean (95% CI)	-0.8 (-2.5 to 0.6)
R - mean (95% CI)	-0.7 (-2.1 to 0.4)
Adjusted difference in change - mean (95% CI)*	0.0 (-2.1 to 2.1)

Data presented are mean changes (95% confidence intervals). * The differences in change are the treatment effects or between groups differences in change (95% CI), with adjustment for the baseline values. A positive difference in change signifies more improvement over time with NIPPV + PR relative to PR alone.
The CRQ (chronic respiratory questionnaire) contains a total score (score range from best (140) to worst (20)), and 4 different domains: dyspnea domain (score range from best (35) to worst (5)), fatigue domain (score range from best (28) to worst (4)), emotion domain (score range from best (49) to worst (7)), mastery domain score range from best (35) to worst (5)). N+R: NIPPV + rehabilitation group; R: rehabilitation group.

ISSN: 1465-993X