Table 4 Induced sputum total and differential cell count and mediators when collected with hypertonic saline or mannitol (18 paired samples)
From: Airway inflammation and mannitol challenge test in COPD
Hypertonic saline | Mannitol induced | r | |
|---|---|---|---|
Eosinophils (104/g) | 1.1 (0.5-6.5) | 0.9 (0.3-7.5) | 0.81 (p = < 0.001*) |
Lymphocytes (104/g) | 1.8 (1.0-7.0) | 1.9 (1.0-3.9) | 0.37 (p= 0.132) |
Macrophages (104/g) | 31.7 (13.2-48.7) | 20.5 (12.6-34.4)** | 0.71 (p = 0.001*) |
Neutrophils (104/g) | 111.1 (59.4-231.5) | 108.1 (58.4-160.1) | 0.75 (p = < 0.001*) |
Epithelial cells (104/g ) | 21.3 (14.5-71.2) | 25.5 (12.8-42.3) | 0.61 (p = 0.009*) |
Total cell count (×106/g) | 1.6 (0.8-2.6) | 1.4 (0.8-2.0) | 0.73 (p = 0.001*) |
Gram sputum | 6.9 (5.2-10.9) | 4.0 (2.0-9.0)** | 0.60 (p = 0.006*) |
ECP (ng/ml) | 147.5 (89.5-492.3) | 125.8 (64.1-277.2) | 0.85 (p = < 0.001*) |
IL-8 (pg/ml) | 1925.5 (534.8-7076.0) | 1595 (862.8-3357.2) | 0.72 (p = 0.001*) |
MPO (ng/ml) | 4529.7(1779.4-7414.8) | 5174.3(1203.0-11933) | 0.84 (p = < 0.001*) |