Figure 3
Bacterial numbers in the lungs at 48 hours post-infection. Data are presented as box plots showing CFU/lung (log 10 scale) in wild-type (wt) and Lcn2 knock-out (ko) mice infected with E. coli HB101 or H9049 (both 8 × 107 CFU/mouse) and tested after 48 hours. (A) For E. coli HB101, a statistical significant difference between the CFU in the lungs of wild-type (n = 9) and Lcn2 knock-out mice (n = 8) was observed (p < 0.05). No bacteria were measured in the spleen of these mice. For E. coli H9049, a significant difference was observed for CFU from the lungs (B) (p < 0.01) and spleen (C) (p < 0.05) of wild-type (n = 8) and Lcn2 knock-out (n = 8) mice.