Figure 6
H 4 R antagonism inhibits airway hyperreactivity and dysfunction in allergen challenged lungs. Animals treated with vehicle, JNJ 7777120 (20 mg/kg b.i.d) and anti-IL-13 around an acute(4 ×) ovalbumin challenge were anesthetized 24 h after the last challenge and lung function measured via a small animal ventilator by forced oscillation techniques. Methacholine dose response relationships were obtained for (A) central airway resistance, (B) tissue stiffness and (C) tissue damping. Each plotted value reflects the mean values for each group of mice (n = 6-10/group). Each animal's value reflects the mean of 12 sets of data captured over a 3-minute span after each aerosol challenge was analyzed for individual animals. Significance of each treatment group compared to control vehicle-treated animals is as follows: * P < 0.05, ** P < 0.01, *** P < 0.001