Figure 5
From: PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution
Ontogeny of airspace distribution. Computerized morphometry was used to determine the ontogeny of airspace size and distribution across postnatal maturation in conditionally targeted and littermate control mice. A, Alveolar frequency at 2 and 8 weeks of age. B, Alveolar size at 2 and 8 weeks of age. C, Alveolar duct frequency at 2 and 8 weeks of age. D, Alveolar duct size at 2 and 8 weeks of age. There was a significant (27%) increase in the number of alveoli in the control animals that was not seen in the targeted animals between 2 and 8 weeks of age. There was a significant (15%) increase in the number of alveolar ducts in the targeted animals that was not seen in the control animals between 2 and 8 weeks of age. There was a significant (11%) increase in the size of the alveolar ducts in the targeted animals that was not seen in the control animals between 2 and 8 weeks of age. * p-value is less than 0.05. Error bars represent standard deviation.