Figure 4
From: PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution
Analysis of airspace number and size. Computerized morphometry was used to determine the sizes of individual airspaces in 8 week old conditionally targeted (n = 12) and littermate control (n = 11) mice. A, Frequency of individual airspaces corresponding to the size of alveoli or alveolar ducts. B, Mean size of airspaces defined as alveoli or alveolar ducts. Consistent with RAC, at 8 weeks of age there are 18% fewer alveoli with 32% more alveolar ducts in conditionally targeted animals. Additionally, alveolar ducts are 19% larger, while alveoli are similar in size (4% larger) in targeted animals compared with littermate controls. Error bars represent standard deviation.