Figure 10

Verapamil inhibits ionophore-induced Ca²⁺mobilization. Transient Ca²⁺ signal evoked by ionomycin was measured as relative fluorescent intensity with Fluo 4AM dye in real time with paired manner, in both control and verapamil incubated H441 cells. (A) Original traces showing on-time Ca²⁺ signal digitized in control (red) and verapamil exposed cells (green). (B) Maximal relative change in fluorescent intensity (F_peak/F₀). Nonparametric Mann-Whitney U-test. *P < 0.05 vs Control. n = 3. (C) The time to reach peak signal. Nonparametric Mann-Whitney U-test. *P < 0.05