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Table 5 The main causes of death in 302 decedents.

From: Survival in severe alpha-1-antitrypsin deficiency (PiZZ)

 

All

N = 302

n (%)

Smoker

N = 197

n (%)

Never-smokers

N = 105

n (%)

Respiratory

175 (58)

134 (68)

41 (39)

   Respiratory failure

117

92

25

   Pneumonia

48

34

14

   Pneumothorax

10

8

2

Hepatic

37 (12)

15 (8)

22 (21)

   Liver failure

13

7

6

   Primary liver carcinoma

18

7

11

   Gastrointestinal bleeding

4

-

4

   Intra-abdominal infection

2

1

1

Other

90 (30)

48 (24)

42 (40)

   Malignancy complication

29

14

15

   Cardiovascular accident

23

14

9

   Cerebrovascular accident

14

6

8

   Intra-abdominal infection*

8

6

2

   Gastrointestinal bleeding*

2

1

1

   Pulmonary embolism

6

4

2

   Suicide/accident

5

3

2

   Renal failure

3

-

3

  1. * without known liver disease