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Table 5 Mean induced sputum protein concentrations averaged over the 3 patient visits:

From: Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD

Sputum Protein COPD non-smokers COPD smokers Control non-smokers Control smokers P value
COPD vs controls
Eotaxin2 (pg/mg) # 1244.2 (1638.6) 808.9 (349.6) 297.8 (279.1) 1159.5 (1477.7) 0.16
HGF (ng/mg) # 19.2 (15.4) 18.0 (17.0) 7.6 (5.9) 23.3 (20.9) 0.61
IP-10 (pg/mg) # 1015.3 (814.8) 605.8 (393.0) 395.7 (272.9) 480.6 (988.8) 0.94
KGF (pg/mg) # 771.5 (747.7) 881.4 (851.5) 549.9 (516.4) 1490.1 (1256.2) 0.67
MMP-13 (ng/mg) # 29.5 (25.8) 30.9 (23.8) 15.1 (11.7) 45.8 (38.7) 0.99
TNF-RI (pg/mg) # 2459.5 (1548.9) 2635.7 (2280.7) 1390.2 (1241.6) 3671.3 (2806.4) 0.77
GROα (ng/mg) # 54.9 (63.8) 23.3 (18.3) 7.6 (9.6) 15.7 (14.6) 0.007
TIMP2 (ng/mg) # 21.1 (9.2) 18.6 (17.0) 5.8 (5.9) 11.8 (14.4) 0.09
TNF-RII (pg/mg) # 169.1 (113.9) 255.9 (367.0) 46.7 (42.1) 130.4 (129.8) 0.04
α2 macroglobulin (mg/mg)* 0.008 (0.006) 0.004 (0.002) 0.005 (0.003) 0.06 (0.07) 0.09
ENA-78 (ng/mg)* 3.7 (4.1) 1.9 (1.7) 1.4 (1.6) 1.2 (0.8) 0.36
IL-13 (pg/mg)* 21.3 (31.2) 9.3 (7.1) 8.6 (1.9) 5.7 (1.7) 0.92
IL-15 (ng/mg)* 0.17 (0.32) 0.11 (0.10) 0.08 (0.03) 0.04 (0.02) 0.47
IL-18 (pg/mg)* 160.4 (189.8) 118.9 (74.4) 58.4 (39.1) 100.8 (53.2) 0.32
IL-1β (pg/mg)* 142.6 (170.7) 404.3 (701.8) 22.8 (12.3) 53.2 (23.1) 0.06
IL-1RA (ng/mg)* 87.3 (53.1) 107.6 (87.4) 60.7 (36.1) 130.0 (72.1) 0.64
IL-6 (pg/mg)* 156.5 (182.3) 214.4 (194.7) 13.3 (7.9) 100.8 (88.4) 0.00005
IL-8 (ng/mg)* 13.6 (9.0) 32.7 (35.2) 3.5 (3.0) 9.0 (8.8) 0.005
MCP-1 (pg/mg)* 845.2 (1285.2) 692.2 (957.0) 71.3 (54.6) 237.2 (318.6) 0.01
MMP-2 (ng/mg)* 55.3 (37.9) 41.3 (20.4) 60.1 (71.6) 42.3 (20.5) 0.06
TIMP-1 (ng/mg)* 206.6 (71.5) 193.4 (68.9) 75.5 (70.5) 112.3 (83.5) 0.004
VEGF(pg/mg)* 2653.0 (659.6) 2845.7 (1013.8) 1200.4 (706.5) 1733.6 (819.8) 0.006
  1. Values in brackets are the standard deviations of the mean.
  2. P values were assessed using linear mixed effects models adjusted for age and gender (see methods section for details).
  3. All individual sputum protein values are corrected for total sputum protein concentration.
  4. # = Measured using SearchLight multiplex sandwich ELISA
  5. * = Measured using Luminex bead- based suspension array assays
  6. HGF = hepatocyte growth factor, IP-10 = interferon-inducible protein 10, KGF = keratinocyte growth factor, MMP-13 = matrix metalloproteinase 13, TNF-R1 = tumour necrosis factor receptor I, GROα = growth-related oncogene alpha, TIMP-2 = tissue inhibitors of metalloproteinases 2, TNF-RII = tumour necrosis factor receptor 2, ENA-78 = epithelial neutrophil-activating peptide 78, IL = interleukin, IL-1RA = interleukin 1 receptor antagonist, MCP-1 = monocyte chemotactic protein 1, MMP-2 = matrix metalloproteinase 2, TIMP-1 = tissue inhibitors of metalloproteinases 1, VEGF = vascular endothelial growth factor.
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