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Table 1 Characteristics of the Study Population (flowcytometry) (n = 6)

From: Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD

subject 1 2 3 4 5 6
gender M M F M M M
Age (years) 60 76 63 67 77 69
Smoking history (packyear) 0 0 40 40 35 50
Current or ex smoker NA NA current current ex ex
FEV1 (%pred) 77.0 111.0 94.0 97.0 74 75.0
FEV 1 (L) 2.4 3.0 1.8 2.9 1.9 1.9
FEV 1 /FVC (%) 70 76 68 68 64 58
LABA (Yes/No) No No No No No No
Inhaled CS (Yes/No) No No No No No No
Systemic CS (Yes/No) No No No No No No
Study group Never Smoker Never Smoker COPD* COPD* COPD* COPD*
% Langerin + cells 2.0 5.4 1.7 1.0 0.9 16.5
% DC-SIGN + cells 2.0 14.1 0.8 0.7 1.0 2.9
% BDCA-1 + cells 4.2 14.2 2.5 2.0 2.5 13.4
% BDCA-3 high + cells 20.0 3.7 6.0 7.9 2.5 4.0
% BDCA-1+ cells on LDC 73.5 88.0 80.8 75.0 64.1 14.2
  1. Data are provided per subject. CS: corticosteroids; FEV1: forced expiratory volume in one second postbronchodilator; FVC: forced vital capacity; LABA : long acting β 2 agonist; M: Male, F: Female; (*): spirometry-based diagnosis of COPD according to GOLD criteria.
  2. Flowcytometric data on single cell suspensions are presented as % of HLA-DR positive cells within the low autofluorescent, CD3 negative, CD19 negative cell population. LDC: langerhans-type dendritic cell