Table 1 Characteristics of the Study Population (flowcytometry) (n = 6)
From: Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD
subject | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
gender | M | M | F | M | M | M |
Age (years) | 60 | 76 | 63 | 67 | 77 | 69 |
Smoking history (packyear) | 0 | 0 | 40 | 40 | 35 | 50 |
Current or ex smoker | NA | NA | current | current | ex | ex |
FEV1 (%pred) | 77.0 | 111.0 | 94.0 | 97.0 | 74 | 75.0 |
FEV 1 (L) | 2.4 | 3.0 | 1.8 | 2.9 | 1.9 | 1.9 |
FEV 1 /FVC (%) | 70 | 76 | 68 | 68 | 64 | 58 |
LABA (Yes/No) | No | No | No | No | No | No |
Inhaled CS (Yes/No) | No | No | No | No | No | No |
Systemic CS (Yes/No) | No | No | No | No | No | No |
Study group | Never Smoker | Never Smoker | COPD* | COPD* | COPD* | COPD* |
% Langerin + cells | 2.0 | 5.4 | 1.7 | 1.0 | 0.9 | 16.5 |
% DC-SIGN + cells | 2.0 | 14.1 | 0.8 | 0.7 | 1.0 | 2.9 |
% BDCA-1 + cells | 4.2 | 14.2 | 2.5 | 2.0 | 2.5 | 13.4 |
% BDCA-3 high + cells | 20.0 | 3.7 | 6.0 | 7.9 | 2.5 | 4.0 |
% BDCA-1+ cells on LDC | 73.5 | 88.0 | 80.8 | 75.0 | 64.1 | 14.2 |