Effect of iloprost on survival rate and body weight loss. Mice were intratracheally injected with 3 mg/kg of bleomycin (Bleo) (no iloprost) or Bleo+iloprost (200 μg/kg). In the mice treated with Bleo (no iloprost), the mortality was as high as 60% by day 21; by contrast, the mortality was only 10% in the mice treated with Bleo+iloprost (A). Body weight loss was significantly attenuated in the mice treated with Bleo+iloprost in comparison with those treated with Bleo (no iloprost) (B). Results are expressed as mean ± SEM, n = 20 mice per group, *, p < 0.05, ***, p < 0.0001.