Figure 4

Inflammatory protein level and activation of NF-κB are elevated in the lungs ofNrf2-/-mice. The concentration of TNF-α (A) and MIP-2 (B) in bronchoalveolar lavage fluid of WT mice (open bars) or Nrf2-/- mice (solid bars) before, and 1 day (Day 1) and 3 days (Day 3) after bleomycin administration. n = 4 in each group. *Significant difference (p < 0.05) between WT mice and Nrf2-/- mice. (C) Nuclear localization of NF-κB (p65) in the lungs of WT mice or Nrf2-/- mice (KO) before, and 1 day (Day 1) and 3 days (Day 3) after bleomycin administration. Lamin B was used as an internal control.