Figure 2
From: Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance
Bleomycin-induced pulmonary inflammation is enhanced inNrf2-/-mice. (A) Representative photographs of lungs from WT mice and Nrf2-/- mice before, and 1 day (Day 1), and 3 days (Day 3) after treatment with bleomycin. Magnification: ×40. (B) The numbers of total cells, macrophages, neutrophils, and lymphocytes in bronchoalveolar lavage fluid of WT mice (open bars) and Nrf2-/- mice (solid bars) before, and 1 day (Day 1), 3 days (Day 3), and 8 days (Day 8) after treatment with bleomycin. n = 8 in each group. (C) Lung wet-to-dry ratio of WT mice (open bars) and Nrf2-/- mice (solid bars) before, and 1 day (Day 1), and 3 days (Day 3) after treatment with bleomycin. n = 8 in each group. (D) The activity of lactate dehydrogenase (LDH) in bronchoalveolar lavage fluid of WT mice (open bars) and Nrf2-/- mice (solid bars) before, and 1 day (Day 1), 3 days (Day 3), and 8 days (Day 8) after treatment with bleomycin. n = 8 in each group. *Significant difference (p<0.05) between WT mice and Nrf2-/- mice.