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Table 1 Pathways significantly modulated by LPS induced lung inflammation as found in MetaCore

From: Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils

Main cellular process Modulated pathways P value Genes in pathway
     Expressed total
   + PMN - PMN + PMN - PMN  
Cell cycle Role of APC in cell cycle regulation 1,040E-09 8,149E-08 15 12 32
  Chromosome condensation in prometaphase 4,131E-06 8,392E-11 9 12 20
  The metaphase checkpoint 4,423E-06 1,474E-04 12 9 36
  Spindle assembly and chromosome separation 3,170E-04 1,937E-03 9 7 32
  Start of DNA replication in early S phase 1,284E-03 3,115E-02 8 5 31
  Initiation of mitosis 1,544E-03 2,483E-03 7 6 25
  Sister chromatid cohesion 1,530E-02   5   21
  Transition and termination of DNA replication   1,523E-02   5 26
  Role of Nek in cell cycle regulation   2,390E-02   5 29
  Nucleocytoplasmic transport of CDK/Cyclins   4,386E-02   3 14
Immune response Alternative complement pathway 4,539E-07 2,737E-02 12 5 30
  Fc gamma R-mediated phagocytosis 1,606E-03 9,058E-03 8 6 32
  Antigen presentation by MHC class II 6,046E-03 2,644E-03 4 4 11
  Classic complement pathway 1,517E-05   12   40
  Antiviral actions of Interferons 2,431E-04   9   31
  CCR3 signalling 8,728E-04   12   59
  Lectin Induced complement pathway 1,251E-03   9   38
  Lipoxin inhibitory action on Superoxide production 1,544E-03 2,483E-03 7 6 25
  IFN alpha/beta signalling pathway 6,214E-03   6   24
  IL-10 signalling pathway 2,245E-02   5   23
  Antigen presentation by MHC class I 3,675E-02   5   26
  Transcription regulation of granulocyte development   3,115E-02   5 31
Oxidative stress ROS production 8,932E-04 4,113E-02 7 4 23
Apoptosis Inhibition of ROS induced apoptosis 3,675E-02   5   26
G protein signalling Rac2 regulation pathway 4,957E-03 4,113E-02 6 4 23
  RAC1 in cellular process 1,361E-02   6   28
Cytoskeleton remodelling Regulation of actin cytoskeleton by Rho GTPases 8,972E-03    5 23
  Alpha-1A adrenergic receptor-dependent inhibition of PI3K 2,887E-02    3 12
Metabolic process Lipoprotein metabolism I. Chylomicron, VLDL and LDL metabolism 1,630E-02 9,007E-07 3 6 8
  Lipoprotein metabolism II. HDL metabolism 1,630E-02 9,007E-07 3 6 8
  G-alpha(q) regulation of lipid metabolism 2,245E-02   5   23
  Urea cycle 3,675E-02   5   26
  LDL metabolism during development of fatty streak lesion 1,870E-02    2 4
  1. Note: Significantly modulated 1.5-fold changed genes (P value < 0.05) versus total number of genes in pathway