Table 1 Pathways significantly modulated by LPS induced lung inflammation as found in MetaCore
Main cellular process | Modulated pathways | P value | Genes in pathway | |||
|---|---|---|---|---|---|---|
Expressed | total | |||||
+ PMN | - PMN | + PMN | - PMN | |||
Cell cycle | Role of APC in cell cycle regulation | 1,040E-09 | 8,149E-08 | 15 | 12 | 32 |
Chromosome condensation in prometaphase | 4,131E-06 | 8,392E-11 | 9 | 12 | 20 | |
The metaphase checkpoint | 4,423E-06 | 1,474E-04 | 12 | 9 | 36 | |
Spindle assembly and chromosome separation | 3,170E-04 | 1,937E-03 | 9 | 7 | 32 | |
Start of DNA replication in early S phase | 1,284E-03 | 3,115E-02 | 8 | 5 | 31 | |
Initiation of mitosis | 1,544E-03 | 2,483E-03 | 7 | 6 | 25 | |
Sister chromatid cohesion | 1,530E-02 | 5 | 21 | |||
Transition and termination of DNA replication | 1,523E-02 | 5 | 26 | |||
Role of Nek in cell cycle regulation | 2,390E-02 | 5 | 29 | |||
Nucleocytoplasmic transport of CDK/Cyclins | 4,386E-02 | 3 | 14 | |||
Immune response | Alternative complement pathway | 4,539E-07 | 2,737E-02 | 12 | 5 | 30 |
Fc gamma R-mediated phagocytosis | 1,606E-03 | 9,058E-03 | 8 | 6 | 32 | |
Antigen presentation by MHC class II | 6,046E-03 | 2,644E-03 | 4 | 4 | 11 | |
Classic complement pathway | 1,517E-05 | 12 | 40 | |||
Antiviral actions of Interferons | 2,431E-04 | 9 | 31 | |||
CCR3 signalling | 8,728E-04 | 12 | 59 | |||
Lectin Induced complement pathway | 1,251E-03 | 9 | 38 | |||
Lipoxin inhibitory action on Superoxide production | 1,544E-03 | 2,483E-03 | 7 | 6 | 25 | |
IFN alpha/beta signalling pathway | 6,214E-03 | 6 | 24 | |||
IL-10 signalling pathway | 2,245E-02 | 5 | 23 | |||
Antigen presentation by MHC class I | 3,675E-02 | 5 | 26 | |||
Transcription regulation of granulocyte development | 3,115E-02 | 5 | 31 | |||
Oxidative stress | ROS production | 8,932E-04 | 4,113E-02 | 7 | 4 | 23 |
Apoptosis | Inhibition of ROS induced apoptosis | 3,675E-02 | 5 | 26 | ||
G protein signalling | Rac2 regulation pathway | 4,957E-03 | 4,113E-02 | 6 | 4 | 23 |
RAC1 in cellular process | 1,361E-02 | 6 | 28 | |||
Cytoskeleton remodelling | Regulation of actin cytoskeleton by Rho GTPases | 8,972E-03 | 5 | 23 | ||
Alpha-1A adrenergic receptor-dependent inhibition of PI3K | 2,887E-02 | 3 | 12 | |||
Metabolic process | Lipoprotein metabolism I. Chylomicron, VLDL and LDL metabolism | 1,630E-02 | 9,007E-07 | 3 | 6 | 8 |
Lipoprotein metabolism II. HDL metabolism | 1,630E-02 | 9,007E-07 | 3 | 6 | 8 | |
G-alpha(q) regulation of lipid metabolism | 2,245E-02 | 5 | 23 | |||
Urea cycle | 3,675E-02 | 5 | 26 | |||
LDL metabolism during development of fatty streak lesion | 1,870E-02 | 2 | 4 | |||