Table 3 Lung function parameters per genotype for non-atopic children with lung function available (population sub-sample from Munich and Dresden)

TT

100.17 ± 10.12

99.08 ± 30.67

99.33 ± 21.57

100.21 ± 18.57

99.44 ± 22.16

100.30 ± 10.38

771

TA

100.15 ± 10.22

100.15 ± 31.74

100.33 ± 23.29

99.81 ± 19.07

99.26 ± 21.89

100.61 ± 11.05

247

AA*

98.18 ± 10.11

80.64 ± 29.50

89.85 ± 24.46

99.08 ± 21.07

88.82 ± 24.57

100.29 ± 9.17

14

p-value (t-test) *

0.468

0.100**

0.101

0.837

0.087

0.976

rs2664538

FEV1%

(Mean ± SD)

MEF25%

(Mean ± SD)

MEF50%

(Mean ± SD)

MEF75%

(Mean ± SD)

MMEF %

(Mean ± SD)

FVC %

(Mean ± SD)

N

AA

99.63 ± 10.58

97.73 ± 31.47

98.67 ± 21.18

99.12 ± 18.76

98.55 ± 22.70

99.82 ± 10.76

445

AG

100.35 ± 9.70

100.71 ± 30.15

100.03 ± 21.52

100.45 ± 18.42

99.58 ± 21.24

100.25 ± 10.31

499

GG

99.82 ± 10.60

100.04 ± 32.92

100.11 ± 25.31

102.29 ± 19.88

101.27 ± 23.54

100.47 ± 11.40

148

p-value (t-test) *

0.832

0.792

0.709

0.138

0.297

0.655

rs3918256

FEV1%

(Mean ± SD)

MEF25%

(Mean ± SD)

MEF50%

(Mean ± SD)

MEF75%

(Mean ± SD)

MMEF %

(Mean ± SD)

FVC %

(Mean ± SD)

N

AA

99.91 ± 10.75

99.40 ± 31.79

99.21 ± 21.61

99.43 ± 19.22

99.72 ± 23.65

99.92 ± 10.66

354

AG

100.07 ± 9.71

99.87 ± 29.97

99.32 ± 21.32

99.93 ± 18.14

99.00 ± 20.55

100.05 ± 10.40

555

GG

100.03 ± 10.46

99.51 ± 32.84

100.79 ± 24.33

102.91 ± 19.85

100.98 ± 23.50

100.58 ± 11.08

206

p-value (t-test) *

0.983

0.941

0.371

0.116**

0.353

0.478

rs3787268

FEV1%

(Mean ± SD)

MEF25%

(Mean ± SD)

MEF50%

(Mean ± SD)

MEF75%

(Mean ± SD)

MMEF %

(Mean ± SD)

FVC %

(Mean ± SD)

N

GG

99.85 ± 10.34

98.32 ± 31.60

99.00 ± 22.14

99.26 ± 19.17

98.67 ± 22.68

100.12 ± 10.67

637

GA

100.31 ± 9.35

99.64 ± 28.68

100.02 ± 20.53

101.47 ± 17.29

99.71 ± 20.97

100.55 ± 9.84

341

AA

101.98 ± 11.61

105.31 ± 36.01

100.09 ± 28.76

101.71 ± 21.39

103.50 ± 23.16

101.91 ± 12.33

58

p-value (t-test) *

0.150

0.125

0.806

0.507

0.170

0.249