MMP-9 gene variants increase the risk for non-atopic asthma in children

Respiratory Research

Table 1 Successful genotyping call rates (Call R in %), minor allele frequencies (MAF), and test for deviation from Hardy-Weinberg Equilibrium (pHWE)

bin	SNP number	Position (to ATG)	Position in the Gene Structure	MAF (HapMap database)	rs Number	LD with tagging SNP	Tagging SNP	MAF (ISAAC sample)	CallR%	test for HWE**
1	1	-1831	Promotor	0.19	rs3918241	1.0	rs3918241	0.15	91.65	NS
	4	2127	Intron 4	0.19	rs2274755	1.0
	6	3009	Intron 6	0.19	rs2236416	1.0
	9	5545	Exon 12*	0.19	rs2274756	1.0
	10	6026	Exon 13*	0.22	rs3918261	0.82
	11	7773	3'	0.19	rs3918270	1.0
	2	570	Intron 1	0.40	rs3918249	0.96
2	5	2659	Exon 6*	0.38	rs2664538	1.0	rs2664538	0.36	94.63	NS
	3	1945	Intron 3	0.46	rs3918253	1.0
3	7	3394	Intron 7	0.46	rs3918256	1.0	rs3918256	0.44	95.97	NS
4	8	4165	Intron 8	0.18	rs3787268	1.0	rs3787268	0.22	91.84	NS

* coding SNPs, ** p value for comparison between observed genotyping frequencies and frequencies estimated by Hardy-Weinberg equilibrium were not significant (NS).

ISSN: 1465-993X