Table 1 Effect of T0901317 on Carrageenan(CAR)-induced inflammation, TNF-α, IL-1β and Nitrite Nitrate production in the pleural exudate

Sham + Vehicle

0.06 ± 0.03

0.4 ± 0.12

8.0 ± 0.6

6.0 ± 1.3

12 ± 1

Sham + T0901317

(20 mg/kg)

0.07 ± 0.05

0.5 ± 0.18

9.0 ± 0.7

7.0 ± 2.2

11 ± 1.2

CAR + Vehicle

1.2 ± 0.12*

9.5 ± 0.9*

55 ± 4.5*

151 ± 12*

135 ± 18*

CAR + T0901317

(20 mg/kg)

0.20 ± 0.1°

2.5 ± 0.18°

19 ± 1.5°

35 ± 7.5°

40 ± 3.5°

CAR + T0901317

(10 mg/kg)

0.41 ± 0.14°

4.5 ± 0.22°

29 ± 1.6°

65 ± 6.8°

74 ± 4.5°

CAR + T0901317

(5 mg/kg)

0.90 ± 0.15^#

7.5 ± 0.35^#

32 ± 2.5^#

95 ± 4.5^#

100 ± 2.4^#