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Table 2 Median cytokine expression in unstimulated and rhinovirus 16 exposed cultures.

From: Adaptive immunity to rhinoviruses: sex and age matter

   Unstimulated RV16 Treated
Age Cytokine (pg/ml) Total cohort: Median IQ range Total cohort: Median IQ range
Total Cohort IP-10 180 77 - 499 5393 3481 - 6891 **
  IFNγ 0 0 - 17 1890 343 - 3915 **
  IL-13 0 0 - 44 47 0 - 87 **
   Female: Male: Female: Male:
   Median and IQ range Median and IQ range Median and IQ range Median and IQ range
≤50 years old IP-10 150 (42 - 504) 258 (66 - 720) 4003 (2781 - 7252) 4571 (2927 - 5861)
  IFNγ 0 (0) 0 (0) 3423 (1766 - 4449) 969 (419 - 3525) *
  IL-13 43 (20 - 67) 23 (0 - 60) 70 (51 - 306) 36 (0 - 45) *
≥52 years old IP-10 107 (75 - 370) 237 (119 - 526) 5917 (3932 - 6904) 5631 (3732 - 7153)
  IFNγ 0 (0) 0 (0) 1641 (205 - 4766) 1403 (158 - 3879)
  IL-13 0 (0 - 46) 0 (0) 11 (0 - 177) 33 (0 - 82)
  1. PBMC were exposed to RV16 and culture supernatant was collected at 24 hours to measure IP-10, and at 5 days to measure IFNγ and IL-13. Median cytokine values, with interquartile (IQ) range for unstimulated and RV16 exposed are shown. Data was assessed for normality and natural log transformed before group comparisons were made using paired two-tailed t-test. Only comparisons attaining p < 0.05 were considered significant and only these p values are shown.
  2. * Male vs. Female, RV16 treated: p < 0.01 ** Total cohort, unstimulated vs. RV16 treated: p < 0.001