Table 1 Pathologic score, airway obstruction, PAS and MUC 5AC positive cells in the airway epithelium.
From: JNK activation is responsible for mucus overproduction in smoke inhalation injury
| Â | Intubation only | Smoke 15 min and 4 h recovery | Smoke 15 min and 24 h recovery | ||||||
|---|---|---|---|---|---|---|---|---|---|
Group | Wild type (WC) | JNK inhibitor (JIC) | JNK -/- (JKOC) | Wild type (WS4) | JNK inhibitor (JIS4) | JNK -/- (JKOS4) | Wild type (WS24) | JNK inhibitor (JIS24) | JNK -/- (JKOS24) |
Pathologic score | 0.5 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.2 | 7.8 ± 1.6* | 2.1 ± 0.4 | 1.1 ± 0.3 | 6.4 ± 1.2* | 1.8 ± 0.4 | 0.9 ± 0.2 |
Airway obstruction (%) | 9.4 ± 2.1 | 8.1 ± 1.5 | 9.1 ± 1.3 | 36.8 ± 9.1* | 15.1 ± 3.4 | 12.1 ± 4.3 | 28.4 ± 5.7* | 12.6 ± 4.4 | 11.0 ± 3.7 |
PAS positive cells (%) | 0.4 ± 0.2 | 0.3 ± 0.2 | 0.3 ± 0.1 | 25.8 ± 7.8* | 3.1 ± 1.4 | 1.9 ± 1.2 | 18.8 ± 3.7* | 2.4 ± 1.6 | 1.1 ± 0.4 |
MUC5AC positive cells (%) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.1 | 23.0 ± 7.3* | 2.8 ± 1.6 | 2.2 ± 0.9 | 17.8 ± 3.1* | 3.4 ± 1.3 | 1.7 ± 0.9 |