Skip to main content

Advertisement

Table 2 Currently available drug regimens for the treatment of latent tuberculosis infection

From: New approaches in the diagnosis and treatment of latent tuberculosis infection

Drug(s) Adult maximum
dose(s) (mg)
Duration of treatment Drug intake Frequency Comments
INH 300 9 months Self administered Daily Preferred regimen by CDC
INH 900 9 months Under DOT 2/Wk Alternative regimen
INH 300 6 months Self administered Daily For HIV seronegative only
INH 900 6 months Under DOT 2/Wk For HIV seronegative only
INH 300 12 months Self administered Daily Preferred regimen by IUAT
RMP 600 4 months Self administered Daily For LTBI with INHr strain in HIV seronegative subjects
INH + RMP 300 + 600 3 months Self administered Daily Good alternative option
RMP + PZA 600 + 2000 2 months Self administered Daily Higher risk of hepatotoxicity
RMP + PZA 600 + 2500 2 months Under DOT 2/Wk Higerh risk of hepatotoxicity
INH + RPE 900 + 900 3 months Under DOT 1/Wk Promising option
  1. INH, isoniazid; RMP, rifampicin; PZA, pyrazinamide; RPE, rifapentine; DOT, directly observed treatment; 2/Wk, twice weekly; 1/Wk, once weekly; CDC, Center for Disease Control and Prevention; HIV, human immunodeficiency virus; IUAT, international Union Against Tuberculosis; LTBI, latent tuberculosis infection