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Table 2 Small airway characteristics

From: Variability in the precursor proteins of collagen I and III in different stages of COPD

  Non-smoker n = 15 Smoker n = 32 COPD stage I-II n = 35 COPD stage IV n = 8 p-value ANOVA
Airway diameter, mm      
Longest 0.89 (0.70) 0.72 (0.36) 0.84 (0.60) 0.70 (0.40) 0.759
Shortest 0.40 (0.50) 0.26 (0.174) 0.30 (0.21) 0.07 (0.03) 0.085
Average 0.64 (0.54) 0.49 (0.24) 0.48 (0.27) 0.40 (0.21) 0.503
Internal lumen      
perimeter, mm 3.17 (2.14) 2.60 (1.45) 2.48 (1.25) 2.17 (1.04) 0.587
Area, mm2 0.45 (0.85) 0.17 (0.16) 0.26 (0.28) 0.09 (0.14) 0.248
Basement membrane      
Perimeter, mm 3.30 (2.25) 2.72 (1.46) 2.47 (1.22) 2.34 (1.11) 0.591
Area, mm2 0.56 (0.93) 0.26 (0.21) 0.29 (0.30) 0.17 (0.17) 0.239
Epithelial area, mm2 0.11 (0.10) 0.09 (0.08) 0.09 (0.09) 0.08 (0.06) 0.938
Thickness of airway wall within RBM** (μm) 23.3 (12.3) 26.1 (9.6) 30.9 (11.1) 22.0 (4.7) 0.029
  1. mean (SD)
  2. n = number of bronchioli studied
  3. *statistically significant difference compared to stage IV COPD
  4. **RBM = reticular basement membrane, including the membrane itself