Figure 3
From: Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis
Schematic diagram of the experimental protocol. Specific pathogen-free, 6-week-old female SD rats (200-250 g body weight) were treated with 3 mg/kg bleomycin (BLM) dissolved in 5 ml of endotoxin-free water via inhalation. Bone marrow-derived mesenchymal stem cells (1 × 106) were administered via a tail vein on day 4 after BLM treatment. The rats were killed on days 0, 7, 14, 21, and 28. Lung specimens were obtained before and after bronchoalveolar lavage as described in the Materials and Methods.