MicroRNAs in inflammatory lung disease - master regulators or target practice?

Respiratory Research

Table 1 Selected miRNA implicated in inflammatory lung disease

miRNA	Tissue/Cell Type	Species	Condition/treatment	Validated Target Genes	References
Let-7d	Lung biopsies	Human	IPF	HMGA2	[124]
miR-21	Whole lung	Mouse	Asthma	IL-12p35	[94]
	Macrophages
	Dendritic cells
	Lung biopsies	Human	IPF	Smad, Smad7	[125]
miR-126	Primary bronchial epithelial cells	Human	CF	TOM1, Tollip	[112]
	Lower airway tissue	Mouse	Asthma	OBF.1	[120]
miR-133a	Bronchial smooth muscle cells	Human	Asthma	RhoA	[97]
miR-146a	Lung alveolar epithelial cells	Human	IL-1β	IL-8, RANTES	[67]
miR-218	Primary bronchial epithelial cells	Human	CSE	MAFG	[87]
miR148a,b, Human miR-152	Primary bronchial epithelial cells		Asthma	HLA-G	[24]
# Let-7c miR-34c miR-222	Whole lung	Rat	CSE	ND	[86]
miR-26b, 27a, miR-31*, 96,	Primary bronchial epithelial cells	Human	DEP	ND	[88]
miR-135b,274a,
miR-338-5p, 494,
miR-513a-5p, b, c,
miR-923
Let-7a, b, f,	Whole lung	Mouse	CSE	ND	[85]
miR-26a, 30b, c,
miR-34b, 99b, 122a,
miR-124a, 125a, b, 140,
miR-192, 431

CSE; cigarette smoke extract, ND; not determined, DEP; diesel exhaust particulate, # 3 of 24 down-regulated miR's validated by qRT-PCR

ISSN: 1465-993X