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Table 4 Risk of infection is increased for 'Minimal' CFTR function using any definition of infection with Pseudomonas aeruginos a, mucoid Pseudomonas aeruginosa and Aspergillus fumigatus.

From: Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients

 

Total Positive

(n included in analysis)

'Minimal' Function

(% of class positive)

'Residual' Function

(% of class positive)

Adjusted Hazards Ratioa

FirstInfx Pa

318 (436)

278 (79.4%)

40 (46.5%)

3.17 (2.10, 4.78)

ChronInfx Pa

127 (436)

118 (33.7%)

9 (10.5%)

5.47 (2.20, 13.58)

MultiInfx Pa

229 (436)

206 (58.9%)

23 (26.7%)

3.81 (2.32, 6.28)

PersInfx Pa

228 (436)

203 (58.0%)

25 (29.1%)

3.32 (2.00, 5.50)

FirstInfx M Pa

492 (919)

453 (56.3%)

39 (33.9%)

2.93 (2.09, 4.09)

ChronInfx M Pa

230 (919)

217 (27.0%)

13 (11.3%)

3.85 (2.00, 7.39)

MultiInfx M Pa

381 (919)

354 (44.0%)

27 (23.5%)

3.11 (2.09, 4.62)

PersInfx M Pa

371 (919)

345 (42.9%)

26 (22.6%)

3.14 (2.06, 4.76)

FirstInfx Asp

451 (1090)

427 (44.0%)

24 (20.0%)

3.77 (2.24, 6.35)

ChronInfx Asp

89 (1090)

88 (9.1%)

1 (0.8%)

18.97 (3.73, 96.43)

MultiInfx Asp

252 (1090)

237 (24.4%)

15 (12.5%)

3.22 (1.73, 5.98)

PersInfx Asp

254 (1090)

243 (25.1%)

11 (9.2%)

4.83 (2.47, 9.46)

  1. Definition of abbreviations: Pa: Pseudomonas aeruginosa, MPa: mucoid Pseudomonas aeruginosa, Asp: Aspergillus fumigatus, FirstInfx: one positive culture for the organism; MultiInfx: three or more positive cultures for the organism; PersInfx: at least one positive culture for the organism in two of three consecutive years; ChronInfx: three positive cultures within 6 months each positive culture at least 1 month from the last positive culture.
  2. a: Adjusted for FEV1BeforeInfx and number of cultures.