Skip to main content

Table 1 Functional potencies and maximal effects of human hemokinin-1 and various tachykinin peptides on guinea-pig trachea.

From: Expression and function of human hemokinin-1 in human and guinea pig airways

Agonist N pD2 Emax (% of Ach 3 mM)
hHK-1 12 6.4 ± 0.03 73 ± 5
EKA/B 6 ND ND
SP 12 6.7 ± 0.1 84 ± 2
[Sar9,Met(O2)11] SP 12 7.5 ± 0.1 76 ± 2
NKA 6 8.1 ± 0.1 95 ± 2
[β-Ala8]-NKA (4-10) 6 8.3 ± 0.6 80 ± 5
  1. hHK-1: human hemokinin-1, EKA/B: endokinin A/B, SP: substance P, NKA: neurokinin A
  2. ND: not determined because an asymptote was not reached with the highest concentration (1 μM) applied.
  3. Values are presented as pD2 and percentage of maximal contraction obtained with Ach 3 mM (mean ± s.e.m.) for n determinations.