Table 2 Treatment contrasts of trough FEV₁ (L) after 1 and 14 days of treatment (mITT population)

Day 14

Indacaterol 150 μg - Placebo

0.17 ± 0.023

(0.12,0.22)

< 0.001*

Indacaterol 300 μg - Placebo

0.15 ± 0.023

(0.10,0.20)

< 0.001*

Tiotropium - Placebo

0.12 ± 0.023

(0.07,0.17)

< 0.001*

Indacaterol 150 μg - Tiotropium

0.05 ± 0.023

(-0.01,0.10)

0.043

Indacaterol 300 μg - Tiotropium

0.03 ± 0.023

(-0.03,0.08)

0.249

LS mean ± SE

95% CI

p-value

Day 1

Indacaterol 150 μg - Placebo

0.10 ± 0.021

(0.06,0.15)

<0.001*

Indacaterol 300 μg - Placebo

0.13 ± 0.021

(0.09,0.17)

<0.001*

Tiotropium - Placebo

0.10 ± 0.021

(0.06,0.14)

<0.001*

Indacaterol 150 μg - Tiotropium

0.01 ± 0.021

(-0.04,0.05)

0.772

Indacaterol 300 μg - Tiotropium

0.03 ± 0.021

(-0.01,0.08)

0.101