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Table 1 Expression of VEGF-A and FGF-2 upon subacute and chronic air or CS-exposure in lungs of WT and Ptx3 KO mice

From: Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

4 weeks

 

WT-Air

WT-CS

Ptx3 KO-Air

Ptx3 KO-CS

VEGF-A/HPRT mRNA

1.00 ± 0.04

0.72 ± 0.04**

1.13 ± 0.09

0.78 ± 0.03*

FGF-2/HPRT mRNA

1.03 ± 0.03

0.85 ± 0.04*

1.12 ± 0.05

0.87 ± 0.10*

VEGF-A (pg/ml)

610.5 ± 16.8

432.4 ± 18.3***

506.3 ± 16.4

412.5 ± 18.3**

FGF-2 (pg/ml)

2066.3 ± 44.3

3703.8 ± 120.8***

1933.8 ± 101.9

3892.5 ± 96.8***

24 weeks

 

WT-Air

WT-CS

Ptx3 KO-Air

Ptx3 KO-CS

VEGF-A/HPRT mRNA

1.11 ± 0.06

0.76 ± 0.05**

1.11 ± 0.05

0.65 ± 0.05**

FGF-2/HPRT mRNA

1.12 ± 0.02

0.93 ± 0.02**

1.20 ± 0.09

0.89 ± 0.07*

VEGF-A (pg/ml)

527.4 ± 16.0

435.3 ± 17.8**

577.2 ± 10.4

396.00 ± 21.0***

FGF-2 (pg/ml)

1196.1 ± 18.4

1974 ± 62.5***

1163.7 ± 33.0

1946.8 ± 56.0***

  1. Data are presented as mean ± SEM. WT: wild-type, Ptx3 KO: Ptx3 knockout, CS: cigarette smoke.
  2. * p < 0.05, ** p < 0.01 and *** p < 0.001 versus air-exposed mice of same genotype
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Respiratory Research

ISSN: 1465-993X

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