Quercetin treatment reduces TBARS and increasesHmox-1expression in elastase/LPS exposed mice. Mice exposed to PBS or elastase/LPS were orally gavaged with 0.2 mg of quercetin or vehicle daily for 10 days and sacrificed on the last day of quercetin treatment. A to D. Elastase/LPS exposed mice show increased levels of TBARS, increased iNOS mRNA levels, decreased Hmox-1 mRNA and increased ratio of iNOS/Hmox-1 compared to PBS exposed mice treated with either vehicle or quercetin. Quercetin treatment reduces TBARS, increases Hmox-1 mRNA and decreases ratio of iNOS/Hmox-1 in elastase/LPS-exposed mice. Data represent mean and SEM (n = 10-14, *different from PBS/vehicle and PBS/quercetin group, p≤0.05; † different from vehicle treated elastase/LPS-exposed mice, p≤0.05 one-way ANOVA).