Table 1 Genes identified from individual studies
From: Asthma susceptible genes in Chinese population: A meta-analysis
| Gene | Chromosome location of gene | Polymorphism | Aminoacid change | Genetic model | Genotypes Evaluated | Other genotypes | Cases | Controls |
|---|---|---|---|---|---|---|---|---|
| β2-AR | 5q31-32 | -46G/A | Arg16Gly | Recessive | GG | GA+AA | 1796 | 1589 |
| -79G/C | Gln27Glu | Recessive | GG | GC+CC | 823 | 692 | ||
| IL-4R | 16p11.2-12.1 | -1902G/A | Q576R | Dominant | GG+GA | AA | 2308 | 1971 |
| -223G/A | Ile/Val | Recessive | GG | GA+AA | 1623 | 1304 | ||
| IL-4 | 5q31 | -589C/T | Dominant | CC+CT | TT | 1724 | 1656 | |
| TNF-α | 6p21.1-21.3 | -308A/G | Dominant | AA+AG | GG | 1428 | 1511 | |
| FcεRIβ | 11q13 | -6843G/A | Glu237Gly | Dominant | GG+GA | AA | 1434 | 1276 |
| -109C/T | Recessive | CC | CT+TT | 428 | 371 | |||
| ACE | 17q23 | D/I | Recessive | DD | DI+II | 385 | 335 | |
| IL-13 | 5q31 | -2044A/G | Gln130Arg | Dominant | AA+AG | GG | 1512 | 1351 |
| -1923C/T | Recessive | TT | CC+CT | 645 | 588 | |||
| IL-1β | 2q12-21 | -511C/T | Dominant | TT+TC | CC | 333 | 255 | |
| LT-α | 6q21.3 | +252A/G | Dominant | GG+GA | AA | 674 | 896 | |
| TGF-β1 | 19q13 | -509C/T | Dominant | TT+TC | CC | 406 | 390 | |
| CD14 | 5q31.1 | -159C/T | Dominant | TT+TC | CC | 1381 | 1219 | |
| ADAM33 | 20p13 | T1 | Met764Thr | Recessive | CC | TT+TC | 569 | 512 |
| RANTES | 17q11.2-12 | -28G/C | Dominant | GG+GC | CC | 314 | 229 | |
| -403A/G | Dominant | AA+AG | GG | 343 | 205 |