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Table 1 Patient Characteristics

From: Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?

  Complete remission Current asthma
  (n = 7) Total group
(n = 23)
Negative
PC 20 AMP
(n = 12)
Positive
PC 20 AMP
(n = 11)
Sex (M/F) 2/5 14/9 6/6 8/3
Age (years) 53.0 (32 - 67) 48.0 (35 - 70) 47.5 (35 - 70) 48.0 (38 - 62)
FEV1 (% predicted) 108.0 (102 - 144)*,‡‡ 97 (76 - 131) 96.2 (76.2 - 123) 96.5 (84.8 - 131)
PC20 AMP (mg/ml) >320 >320 (0.02 - >320) >320 12.0 (0.02 - 174)
Cumulative AMP dose (mg) 639.99 639.99 (0.02 - 639.99) 639.99 39.99 (0.02 - 639.99)
PC20 Histamine (mg/ml) >32.0 N.A. 16.9 (2.5 - 32.0) N.A.
Reversibility FEV1 (%) 4.59 (1.76 - 9.72) 5.42 (-2.98 - 26.7) 3.15 (-2.98 - 12.2) 9.40 (1.76 - 26.7)
IgE (IU/L) 47 (7 - 166) 66 (11 - 558) 61 (14 - 246) 78 (11 - 558)
Positive Phadiatop (n (%)) 3 (43) 15 (65) 5 (42) 10 (91)
Eosinophils blood (× 109/L) 0.12 (0.09 - 0.24) 0.15 (0.03 - 0.35) 0.11 (0.03 - 0.35) 0.17 (0.07 - 0.25)
  1. Values are medians (ranges), unless stated otherwise.
  2. Definition of abbreviations: PC20 AMP = provocative concentration of adenosine 5'monophoshate causing a 20% fall in FEV1; reversibility FEV1 = change in FEV1, expressed as increase in percentage predicted normal value after 400 μg of Salbutamol; Positive Phadiatop = specific IgE's in patient serum/control serum >1; n = number; N.A. = not available.
  3. * p ≤ 0.05 versus current asthma total group.
  4. p ≤ 0.05, ‡‡ p ≤ 0.01 versus current asthma PC20 AMP positive.