Figure 6
From: Asthma and genes encoding components of the vitamin D pathway
Two-gene models on asthma involving the IL10 and VDR genes in the SLSJ and the CAMP studies. With two bi-allelic SNPs (3 genotypes per SNP), a 3 by 3 odds ratio matrix is calculated and visually represented. The y-axis shows the odds ratio on a log2 scale, which makes the odds ratio above and below 1 on the same visual scale. The IL10 genotypes are illustrated on the x-axis. Different panels of SNPs were genotyped between the two studies and the comparison for the VDR gene is made with different SNPs that are in LD (D' = 1.0 and r2 = 0.59, based on the HapMap CEU genotyping dataset). In the SLSJ study, the risks are evaluated relative to the VDR-GG and IL10-TT genotypes. In CAMP, the risks are evaluated relative to the VDR-CC and IL10-TT genotypes.