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Table 2 Vascular response of aorta

From: Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig

 

3 months

6 months

ANOVA

 

Control

(n = 9)

CS-Exposed

(n = 6)

Control

(n = 8)

CS-Exposed

(n = 12)

Time

CS

Exposure

Interaction

Contraction

       

KCl (60 mM), mg

3346 ± 290

3224 ± 336

3596 ± 290

3837 ± 237

0.144

0.755

0.537

NE (10 -6 M), mg

1347 ± 192

1621 ± 222

922 ± 192

1037 ± 157

0.012

0.341

0.682

Relaxation to ADP

       

EC 50 , (-log [M] ADP)

7.10 ± 0.10

7.29 ± 0.12

6.97 ± 0.10

6.93 ± 0.08

0.038

0.588

0.260

AUC †

8.21 ± 0.04

8.15 ± 0.05

8.25 ± 0.04

8.23 ± 0.03

0.208

0.440

0.651

Relaxation to ADP+L-NAME

       

EC 50 , (-log [M] ADP)

ND

ND

ND

ND

ND

ND

ND

AUC †

8.80 ± 0.06

8.85 ± 0.08

8.76 ± 0.07

8.67 ± 0.05

0.116

0.661

0.268

Relaxation to SNP

       

EC 50 , (-log [M] SNP)

7.53 ± 0.15

7.26 ± 0.26

8.04 ± 0.13

8.15 ± 0.10

<0.001

0.837

0.286

AUC †

7.91 ± 0.07

7.99 ± 0.08

7.93 ± 0.07

7.88 ± 0.05

0.544

0.991

0.343

  1. Definition of abbreviation: NE: Norepinephrine; ADP: Adenosine diphosphate; SNP: Sodium nitroprusside; EC50: dose that causes 50% of relaxation; AUC: area under the curve; L-NAME: N G-monomethyl-L-arginine
  2. Values are mean ± SEM
  3. †log-transformed
  4. ND: not determined
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Respiratory Research

ISSN: 1465-993X

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