From: Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig
3 months | 6 months | ANOVA | |||||
---|---|---|---|---|---|---|---|
Control (n = 9) | CS-Exposed (n = 6) | Control (n = 8) | CS-Exposed (n = 12) | Time | CS Exposure | Interaction | |
Contraction | |||||||
KCl (60 mM), mg | 3346 ± 290 | 3224 ± 336 | 3596 ± 290 | 3837 ± 237 | 0.144 | 0.755 | 0.537 |
NE (10 -6 M), mg | 1347 ± 192 | 1621 ± 222 | 922 ± 192 | 1037 ± 157 | 0.012 | 0.341 | 0.682 |
Relaxation to ADP | |||||||
EC 50 , (-log [M] ADP) | 7.10 ± 0.10 | 7.29 ± 0.12 | 6.97 ± 0.10 | 6.93 ± 0.08 | 0.038 | 0.588 | 0.260 |
AUC † | 8.21 ± 0.04 | 8.15 ± 0.05 | 8.25 ± 0.04 | 8.23 ± 0.03 | 0.208 | 0.440 | 0.651 |
Relaxation to ADP+L-NAME | |||||||
EC 50 , (-log [M] ADP) | ND | ND | ND | ND | ND | ND | ND |
AUC † | 8.80 ± 0.06 | 8.85 ± 0.08 | 8.76 ± 0.07 | 8.67 ± 0.05 | 0.116 | 0.661 | 0.268 |
Relaxation to SNP | |||||||
EC 50 , (-log [M] SNP) | 7.53 ± 0.15 | 7.26 ± 0.26 | 8.04 ± 0.13 | 8.15 ± 0.10 | <0.001 | 0.837 | 0.286 |
AUC † | 7.91 ± 0.07 | 7.99 ± 0.08 | 7.93 ± 0.07 | 7.88 ± 0.05 | 0.544 | 0.991 | 0.343 |