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Table 1 Vascular response of pulmonary artery

From: Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig

 

3 months

6 months

ANOVA

 

Control

(n = 9)

CS-Exposed

(n = 6)

Control

(n = 8)

CS-Exposed

(n = 12)

Time

CS

Exposure

Interaction

Contraction

       

KCl (60 mM), mg

1825 ± 164

2318 ± 201

1673 ± 174

2694 ± 142

0.554

<0.001

0.134

NE (10 -6 M), mg

1043 ± 118

1058 ± 145

990 ± 125

895 ± 107

0.396

0.703

0.660

Relaxation to ADP

       

EC 50 , (-log [M] ADP)

7.48 ± 0.07

7.28 ± 0.09

7.21 ± 0.07

7.15 ± 0.06

0.009

0.110

0.318

AUC †

7.71 ± 0.03

7.78 ± 0.04

7.83 ± 0.03

7.91 ± 0.03

<0.001

0.037

0.881

Relaxation to ADP+L-NAME

       

EC 50 , (-log [M] ADP)

ND

ND

ND

ND

ND

ND

ND

AUC †

8.34 ± 0.05

8.30 ± 0.05

8.28 ± 0.05

8.27 ± 0.04

0.358

0.619

0.711

Relaxation to SNP

       

EC 50 , (-log [M] SNP)

8.66 ± 0.12

8.66 ± 0.14

8.57 ± 0.14

8.36 ± 0.11

0.137

0.370

0.414

AUC †

7.52 ± 0.06

7.42 ± 0.07

7.59 ± 0.07

7.65 ± 0.05

0.022

0.816

0.201

  1. Definition of abbreviation: NE: Norepinephrine; ADP: Adenosine diphosphate; SNP: Sodium nitroprusside; EC50: dose that causes 50% of relaxation; AUC: area under the curve; L-NAME: N G-monomethyl-L-arginine
  2. Values are mean ± SEM
  3. †log-transformed
  4. ND: not determined
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Respiratory Research

ISSN: 1465-993X

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