Table 5 MMP mRNA levels in the in vivo model of elastase driven experimental emphysema.

2 hrs Vehicle

162.0 ± 14.7

38.4 ± 3.2

1.2 ± 0.2

2 hrs Elastase

168.4 ± 20.4

36.0 ± 2.5

0.7 ± 0.2

6 hrs Vehicle

76.9 ± 8.3

25.0 ± 3.3

0.5 ± 0.1

6 hrs Elastase

86.6 ± 8.3

36.6 ± 4.9

0.7 ± 0.1

24 hrs Vehicle

84.9 ± 10.9

18.3 ± 3.6

0.4 ± 0.04

24 hrs Elastase

59.7 ± 7.7

18.6 ± 2.4

0.2 ± 0.1

*

48 hrs Vehicle

70.8 ± 16.6

9.4 ± 2.0

0.5 ± 0.1

48 hrs Elastase

60.6 ± 4.1

42.2 ± 6.1

*

0.2 ± 0.1

*

72 hrs Vehicle

90.7 ± 9.3

15.5 ± 1.7

0.5 ± 0.1

72 hrs Elastase

74.7 ± 6.2

36.0 ± 5.7

*

0.3 ± 0.1

96 hrs Vehicle

95.6 ± 9.3

17.0 ± 2.4

0.6 ± 0.1

96 hrs Elastase

100.9 ± 11.1

23.5 ± 4.7

0.4 ± 0.05

168 hrs Vehicle

61.9 ± 5.9

16.8 ± 3.2

0.3 ± 0.1

168 hrs Elastase

66.0 ± 8.2

28.8 ± 5.2

0.2 ± 0.1