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Table 5 MMP mRNA levels in the in vivo model of elastase driven experimental emphysema.

From: MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies

  MMP-2 MMP-14 TIMP-4
2 hrs Vehicle 162.0 ± 14.7 38.4 ± 3.2 1.2 ± 0.2
2 hrs Elastase 168.4 ± 20.4 36.0 ± 2.5 0.7 ± 0.2
6 hrs Vehicle 76.9 ± 8.3 25.0 ± 3.3 0.5 ± 0.1
6 hrs Elastase 86.6 ± 8.3 36.6 ± 4.9 0.7 ± 0.1
24 hrs Vehicle 84.9 ± 10.9 18.3 ± 3.6 0.4 ± 0.04
24 hrs Elastase 59.7 ± 7.7 18.6 ± 2.4 0.2 ± 0.1
*
48 hrs Vehicle 70.8 ± 16.6 9.4 ± 2.0 0.5 ± 0.1
48 hrs Elastase 60.6 ± 4.1 42.2 ± 6.1
*
0.2 ± 0.1
*
72 hrs Vehicle 90.7 ± 9.3 15.5 ± 1.7 0.5 ± 0.1
72 hrs Elastase 74.7 ± 6.2 36.0 ± 5.7
*
0.3 ± 0.1
96 hrs Vehicle 95.6 ± 9.3 17.0 ± 2.4 0.6 ± 0.1
96 hrs Elastase 100.9 ± 11.1 23.5 ± 4.7 0.4 ± 0.05
168 hrs Vehicle 61.9 ± 5.9 16.8 ± 3.2 0.3 ± 0.1
168 hrs Elastase 66.0 ± 8.2 28.8 ± 5.2 0.2 ± 0.1
  1. A p-value of less than 0.05 was taken as significant and denoted with *. MMP-3, 10 and 13 were BRDL.