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Table 4 MMP mRNA levels in the in vivo model of LPS induced neutrophilic inflammation.

From: MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies

 

MMP-2

MMP-14

TIMP-4

1 hr Vehicle

90.3 ± 8.3

10.8 ± 0.8

0.3 ± 0.1

1 hr LPS

136.4 ± 35.2

13.2 ± 2.9

0.3 ± 0.1

2 hrs Vehicle

64.6 ± 1.7

9.7 ± 0.3

0.3 ± 0.04

2 hrs LPS

60.4 ± 7.8

10.5 ± 1.5

0.2 ± 0.1

4 hrs Vehicle

82.8 ± 6.8

11.1 ± 1.0

0.2 ± 0.1

4 hrs LPS

89.7 ± 7.7

11.8 ± 1.5

BRDL

6 hrs Vehicle

60.8 ± 13.4

10.4 ± 0.5

0.2 ± 0.04

6 hrs LPS

82.8 ± 10.7

14.1 ± 2.2

BRDL

8 hrs Vehicle

107.9 ± 22.4

19.5 ± 3.7

0.4 ± 0.1

8 hrs LPS

77.5 ± 12.1

23.9 ± 2.6

0.2 ± 0.1

12 hrs Vehicle

110.6 ± 13.0

22.9 ± 3.4

0.2 ± 0.03

12 hrs LPS

79.3 ± 6.8

21.0 ± 1.3

0.3 ± 0.1

24 hrs Vehicle

97.3 ± 13.8

20.8 ± 2.3

0.4 ± 0.1

24 hrs LPS

80.9 ± 3.9 ±

23.6 ± 1.6

0.3 ± 0.1

  1. A p-value of less than 0.05 was taken as significant and denoted with *. MMP-3, 10 and 13 were BRDL.