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Table 4 MMP mRNA levels in the in vivo model of LPS induced neutrophilic inflammation.

From: MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies

  MMP-2 MMP-14 TIMP-4
1 hr Vehicle 90.3 ± 8.3 10.8 ± 0.8 0.3 ± 0.1
1 hr LPS 136.4 ± 35.2 13.2 ± 2.9 0.3 ± 0.1
2 hrs Vehicle 64.6 ± 1.7 9.7 ± 0.3 0.3 ± 0.04
2 hrs LPS 60.4 ± 7.8 10.5 ± 1.5 0.2 ± 0.1
4 hrs Vehicle 82.8 ± 6.8 11.1 ± 1.0 0.2 ± 0.1
4 hrs LPS 89.7 ± 7.7 11.8 ± 1.5 BRDL
6 hrs Vehicle 60.8 ± 13.4 10.4 ± 0.5 0.2 ± 0.04
6 hrs LPS 82.8 ± 10.7 14.1 ± 2.2 BRDL
8 hrs Vehicle 107.9 ± 22.4 19.5 ± 3.7 0.4 ± 0.1
8 hrs LPS 77.5 ± 12.1 23.9 ± 2.6 0.2 ± 0.1
12 hrs Vehicle 110.6 ± 13.0 22.9 ± 3.4 0.2 ± 0.03
12 hrs LPS 79.3 ± 6.8 21.0 ± 1.3 0.3 ± 0.1
24 hrs Vehicle 97.3 ± 13.8 20.8 ± 2.3 0.4 ± 0.1
24 hrs LPS 80.9 ± 3.9 ± 23.6 ± 1.6 0.3 ± 0.1
  1. A p-value of less than 0.05 was taken as significant and denoted with *. MMP-3, 10 and 13 were BRDL.