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Table 6 Family-based haplotype association analysis of IPO13 polymorphisms on methacholine hyperresponsiveness (PC20) in childhood asthma.

From: Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

  Nedocromil/Placebo (global p-value = 0.02) Budesonide (global p-value = 0.58)
Haplotype Number of informative families P-value Number of informative families P-value
A 136 0.41 53 0.33
B 84 0.02 33 0.53
C 69 0.17 20 0.41
D 43 0.48 18 0.50
  1. Haplotype analysis was performed using one of several haplotype-tagging SNP combinations: rs6671164 – rs199150 – rs2428953. The haplotype designations A through D correspond to those illustrated in Figure 1.